Unhealthy lifestyle, routine, smoking, alcohol and junk food are the important parameters that have been into consideration these days due to the problem of blood pressure and coronary artery disease. These problems might be responsible for the cause of sudden cardiac arrest among many of the individuals. In a recent survey it has been found that around 80% of the individuals are suffering from blood pressure related issues of which 40% are suffering from the cardiac disorder.
Amlodipine is a calcium channel blocker that helps in widening the blood vessels and improves the blood flow. It is used to treat chest pain and other pains caused due to coronary artery disease. It helps in lowering the blood pressure caused due to stroke or some other problem.
How Amlodipine acts? Amlodipine helps in reducing the arterial smooth muscle contractility and the following vasoconstriction by inhibiting the incursion of calcium ions through L-type calcium channels. Calcium ions incoming the cell through these channels attach to calmodulin. Calcium-bound calmodulin then binds to and activates the myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin which causes contraction. Signal amplification is achieved by calcium-induced channel and the calcium is released from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilating activity. The vasodilatory effects of Amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina).
Dosage Information for Amlodipine: Amlodipine tablet is available in 10mg extended release tablet that needs to be taken orally with plenty of water and particularly after the meal. It needs to be given once a day for the treatment of Hypertension, Angina Pectoris, and Coronary artery disease. The dose of the medication can be adjusted only after the consultation fromms the doctor. This medication is not to be chewed or broken. Swallow the tablet as a whole. However, some side effects are likely to occur while using the medication such as swelling of ankles, difficulty in breathing, wheezing, dizziness, and bleeding gums.
Precautionary measures: Some precautionary measures that need to be kept in mind while using this medication including; avoid use of this medication in case of any kidney or liver disorders; do not use this medication if you are using any other medication for nervous disorder or seizures; avoid use of the medication during pregnancy and breast feeding; do not take any kind of herbal or dietary supplement along with this medication; Caution is advised for use in children as the efficacy of this medicine has not yet been studied in children below 3 years.
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